Understanding HRR Status
It's key to helping you and your doctor make informed treatment decisions.
HRR Gene Mutations Explained
Homologous recombination repair (HRR) genes are involved in repairing damaged DNA. If you have mutations in HRR genes, not all DNA repair proteins may work properly. This may increase your chances of developing certain types of cancers, including prostate cancer.
Inherited
Passed on from parent to child
Acquired
Can occur randomly and throughout your lifetime
Why HRR Status Matters
For starters, knowing your HRR status can inform your treatment options, including whether you might be eligible for TALZENNA + XTANDI. But it can also:
- Help you and your doctor decide how to manage your prostate cancer
- Help you find out if your family is at an increased risk of developing certain types of cancer, since these mutations may be inherited
How HRR Gene Mutations Are Identified
Your doctor can perform a genetic and/or tumor test to determine if you have HRR gene mutations. Genetic testing can be done using a tissue or blood sample.
~1 in 4 Men With mCRPC Have an HRR Gene Mutation*
*This is an estimate because the studies and data used to determine the occurrence of HRR gene mutation in men with advanced prostate cancer varied in their design and patient characteristics, such as different previous or current drug treatment, coexisting conditions, or disease levels.
Ask About Your HRR Status
Our doctor discussion guide can help you get the conversation started.
