How Treatment May Help
HRR gene-mutated mCRPC = prostate cancer with certain abnormal inherited or acquired genes called homologous recombination repair (HRR genes) that has spread to other parts of the body (metastatic) and no longer responds to a hormone therapy or surgical treatment to lower testosterone (castration-resistant).
The Study
TALZENNA + XTANDI was studied in a clinical trial in adults with HRR gene-mutated mCRPC. The main goal of the study was to look at progression free survival. Progression was defined as the cancer getting worse, as measured by scans, or if the patient died for any reason.
All men either had surgery to lower testosterone or continued to take hormone therapy in the study.
200 patients were given TALZENNA + XTANDI
199 patients were given placebo + XTANDI
The Results
Reduced Risk of Progression
The risk of cancer progression was reduced by 55% with TALZENNA + XTANDI vs. those taking a placebo + XTANDI.
Cancer progression was seen in 66 of the 200 (33.0%) men taking TALZENNA + XTANDI vs.104 of the 199 (52.3%) men taking a placebo + XTANDI.
Progression was defined as the cancer getting worse, as measured by scans, or if the patient died for any reason.
Median Time Until Cancer Progression
During this study, cancer progression was measured by the median. The median is not the average but the middle of a set of numbers. The median time until cancer progression is how long it takes until half of the people in the study’s cancer starts growing or spreading again or if they die for any reason.
The median length of time until the cancer grew or spread was not reached for TALZENNA + XTANDI.* In this clinical trial, patients taking TALZENNA + XTANDI had a 97.5% chance that the median time until cancer progression was at least 21.9 months.
The median length of time until the cancer grew or spread was 13.8 months for a placebo + XTANDI.
More time is needed to find out if patients taking TALZENNA + XTANDI live longer than patients taking placebo + XTANDI.
*What does “median not reached for TALZENNA + XTANDI” mean? “Median not reached” means that more than half of patients were alive without their cancer progressing at the time of analysis.
Talk to your doctor about TALZENNA + XTANDI
Our doctor discussion guide can help you ask more focused questions at your next appointment.
